Preheat the oven according to the dough instructions.
Add the ground beef to a skillet over medium heat. Once it's broken into bite-size pieces add the onion. Season with garlic powder, salt, and pepper.
Once the beef is no longer pink, drain any grease.
Reserve 1/4 cup of the Manwich sauce. Add the rest of the sauce to the ground beef and heat through.
Roll out the pizza dough onto a greased baking sheet, or line it with parchment paper.
Spread the Manwich sauce evenly over the pizza dough, leaving a little bit of space around the edges for the crust.
Top the sauce with the beef mixture, then the shredded cheese. Bake the pizza until the cheese is melted and the crust is golden brown.
Remove the pizza from the oven and let it cool for a few minutes before slicing and serving.