In a small bowl, combine the chili powder, smoked paprika, cumin, garlic powder, onion powder, salt, and pepper. Stir until combined.
Preheat the oven to 350 degrees F. Spray a baking sheet or line it with parchment paper.
Pat the chicken dry and pound to an even thickness, about 1/4 inch.
Season both sides of the chicken breast with the fajita seasoning.
Lay the chicken flat. Sprinkle cheese in the center of the chicken breast, then add a small amount of peppers and onions in the center, then tightly roll up. Secure with a toothpick or place seam-side down in the baking dish.
Lightly spray tops with cooking spray. Bake for 30-35 minutes or until the chicken reaches an internal temperature of 165 degrees F.